George Knapp examined the Bigfoot mystery with writer Philip Spencer during the second hour and David Paulides, noted researcher and author of the Hoopa Project, for the remainder of the show. "It's hard to describe what you feel when you see something like this," Spencer said about his own Bigfoot sighting.

Spencer detailed his investigation of the "Panther Rock" cave in Kentucky, a hotbed of paranormal activity. "Over time, it just seemed to me like all these events were occurring around this cave," he said, citing a litany of anomalies, from unusual animal prints, Bigfoot sightings, strange lights and sounds, and even the mysterious disappearance of a family that had settled there. He also played some audio of potential Bigfoot sounds, captured by a resident of the area.

During the latter half of the program, David Paulides talked about the Hoopa Project, a long term effort aimed at finding Bigfoot evidence focused on Hoopa, California, where his research indicates is a frequent area for sightings. He said that his group has documented a number of Bigfoot cases, ranging from the benign to the terrifying, including "direct sightings, encounters that could be attributed to it, meaning sounds, rock throwing incidents, and at one point a creature reached an arm into a window of a residence."

He also talked about one promising avenue of Bigfoot research that the Hoopa Project has undertaken: using skilled forensic artist Harvey Pratt to create sketches of the creature based on eyewitness testimony. Paulides explained that the Hoopa Project went the additional, and unprecedented, step of actually flying Pratt to California to work directly with the witnesses. During these sessions, Paulides said, the witnesses described human-looking faces for the creature, an observation which contradicts popular opinion of the beast's visage, making their testimony "even more credible to us." Pratt's skills were so sharp that, according to Paulides, that upon seeing the depiction of their Bigfoot sighting, the witness would exclaim, "Oh my God, you’ve got it!"