During the first half of the show, sci-fi writer Marc Zicree joined George in the studio to discuss the new Star Trek film and the classic TV series The Twilight Zone. He was very pleased with new J.J. Abrams version of Star Trek which opens this weekend. Based on the audience he saw it with, Zicree was optimistic that the movie would appeal to both longtime Star Trek fans as well as newcomers to the series. On how he felt fans of the original Trek crew would feel about the new faces playing the iconic Trek characters, Zicree mused that "even the die hard, first generation of Trekkers recognize ... that it's time for new actors to step up and take on those roles."

"He used to joke that he was the only writer who could write a script and get a tan at the same time," Zicree said about Twilight Zone creator Rod Serling and his unique method of writing scripts. He explained that Serling would lounge by his pool and dictate the stories into a recorder, playing the roles of each of the show's characters. From there, the tapes would be transcribed by Serling's secretary and turned into the script. According to Zicree, this novel means of creating episodes allowed for remarkable quickness. "It would take him anywhere from one to three days to write a script," he marveled.

The second half of the program featured Open Lines, including the return of infamous caller J.C., who declared "I cannot keep my silence any longer!" The self-proclaimed "ten star general" of God revealed that he was "broadcasting live from the search" for his former associate Edna. J.C. also decried the earlier discussion on science fiction, calling it "nonsensical nonsense," and relished in the spread of swine flu because "sinners are gonna be dropping in the streets."

The final half hour of the show featured George's 9/27/07 interview with medical intuitive, author and lecturer Stewart Swerdlow discussing mind control.